In real history, I love the Renaissance era. I'm a huge fan of the Osman Empire, which peaked in the 15th and 16th centuries. Furthermore, during the Renaissance, there were many appealing leaders, such as Mehmed II and Matthias Corvinus.
In the Civilization game, I also love the Renaissance era. After some initial maneuvers, it is time to weigh whether you'll win easily, hardly, or lose!