I personally think that a culture victory is by far the hardest victory type since most of the tie you will be heading into the late game before you even get close to acquiring this, and at that point the culture required will be unnecessary. (I am playing a culture victory as of writing this. (Settings: Nzinga Mbande, Standard size (Continents and Islands), Prince, 14 City states, No game modes, Infinite turns, no score victory, no diplomatic victory))