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An [ICBM] (inter-continental ballistic missile) has an unlimited range, and like the tactical nuke, has a devastating effect. They cannot be moved from the city that builds them but can strike any target on the map. Nuclear weapons, if used, have a tremendous negative effect upon world opinion.
The ICBM is the most powerful unit in the Civilization franchise. It has the ability to strike anywhere on the map causing significant damage. When used over a city, it has a damage range of 12 squares. Inside the city, populations are reduced drastically and huge damage can be done to city improvements such as wonders or other buildings. Within 12 squares, the city is affected with pollution and radioactive waste. All the green pastures are destroyed converting the area into desert. Another hit with the ICBM on the same city can send the city back to prehistoric age, leaving a population count of 5 or less.
Other countries can use the ICBM against you and the amount of damage will be the same. However, the ICMB can be countered with the SDI_Defence. This gives you a 70%+ hit rate, destroying enemy ICBM even before they reach your city.
The use of ICBM also causes all the other civilizations to declare war on you and eventually use multiple ICBM's on you. Eventually, if you did built the SDI_Defense system, you are protected against any attack.
Tactics During war preparations, it is recommended for the player to build a massive amount of ICBM's, like 50 something. In case of war, you can deploy a massive nuclear war on any civilization, leaving their country basically defenseless. Eventually, a few Mech infantry or marines are good enough take control