As many people know, Civilization V is suppose to vary a little bit from its' predecessors. MTV Multiplayer have comprised a list of 5 qualities that makes this game different from the past games. They include "Settler Rush, Begone," "City-States," "Manifest Destiny In Close Quarters," "No More Excessive Force," and "Self-Sufficient Cities." To read more about about these differences check out the original article on MTV Multiplayer.
Source: MTV Multiplayer